Name: Recombinant Human Paired Box 8
Price: Inquiry

- Overview
  - PAX8 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids (1-287 a.a) and having a molecular mass of 33.4kDa. PAX8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Paired box 8,also known as PAX8 functions in thyroid follicular cell development as well asin expression of thyroid-specific genes. PAX8 complexes with TTF-1 & TTF-2 inorder to stimulate thyroid follicular cell differentiation and thyroid hormonebiosynthesis by regulating the expression of NIS (sodium iodide symporter) , TPO (thyroidperoxidase), TG (thyroglobulin) and the TSHR (thyrotropin receptor). Defects in PAX8 are the cause of CHNG2 (congenitalhypothyroidism non-goitrous type 2).
    
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- Properties
  - Protein Name
    
    Paired Box 8, Paired Box Gene 8, PAX8.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 90.0% as determined by SDS-PAGE.
    
    Formulation
    
    PAX8 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Paired Box 8

Recombinant Human Paired Box 8

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