Name: Recombinant Human MHC class I chain-related gene B
Price: Inquiry

- Overview
  - MICB Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 326 amino acids and having a molecular mass of 37kDa. The sequence contains the extracellular domain of the mature human MICB (amino acid residues Ala23 - Tyr312). The MICB is purified by proprietary chromatographic techniques. MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with 2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.
    
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- Properties
  - Protein Name
    
    MHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
    
    Formulation
    
    Lyophilized from a concentrated (1mg/ml) solution containing no additives.
    
    Storage
    
    Lyophilized MICB although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MICB should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human MHC class I chain-related gene B

Recombinant Human MHC class I chain-related gene B

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