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Recombinant Human MELK (1-550aa) (N-GST tag)

Recombinant Human MELK (1-550aa) (N-GST tag)

Catalog Number:
E001278428APP
Mfr. No.:
Z500223
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells. MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL. Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          HPK38, KIAA0175
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          88.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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