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Recombinant Human MELK (1-340aa) (N-GST tag)

Recombinant Human MELK (1-340aa) (N-GST tag)

Catalog Number:

E001278429APP

Mfr. No.:

Z500222

Price:

$672

Size:

10 µg

Quantity:

Add to Cart:

- Overview
  - MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells. MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL. Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers.
    
    Please contact us at for specific academic pricing.
- Properties
  - Name
    
    HPK38, KIAA0175
    
    Source
    
    Insect cells
    
    Type
    
    Recombinant Proteins
    
    Formulation
    
    50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
    
    Storage
    
    Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
    
    Molecular Weight
    
    61.0 kDa
    
    Class
    
    Active Kinases
    
    * For research use only. Not for diagnostic or therapeutic use.

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