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Overview
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Lysyl oxidase homolog 2 (LOXL2) is a secreted protein that belongs to the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagens and elastin. LOXL2 is expressed in many tissues, with the highest expression in reproductive tissues, placenta, uterus and prostate, and is up-regulated in a number of cancers cells and tissues. LOXL2 changes the structure of histones and thus changes the shape of the cells, making it easier for the cancer cells to metastasize. LOXL2 expression could also be used as a molecular target in the prevention of breast cancer progression.
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