Name: Recombinant Human Lumican
Price: Inquiry

- Overview
  - LUM Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 343 amino acids (19-338a.a) andhaving a molecular mass of 30.9kDa. LUM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Lumicanalso known as LUM belongs to the small leucine-rich proteoglycan (SLRP) familywhich comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, andosteoglycin. Furthermore we can see that in these bifunctional molecules, theprotein moiety binds collagen fibrils and the highly charged hydrophilicglycosaminoglycans regulateinterfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM isalso distributed in interstitialcollagenous matrices throughout the body. Lumican regulates collagenfibril organization and circumferential growth, corneal transparency,epithelial cell migration and tissue repair. Among the diseases associated withLUM is posterior amorphous corneal dystrophy.
    
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- Properties
  - Protein Name
    
    Lumican, LDC, Lumican Proteoglycan, Keratan Sulfate Proteoglycan Lumican, SLRR2D, KSPG Lumican.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greaterthan 90.0% as determined by SDS-PAGE.
    
    Formulation
    
    LUM protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Recombinant Human Lumican

Recombinant Human Lumican

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