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Overview
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LSM2 Human Recombinant produced in E. coli is a single polypeptide chain containing 119 amino acids (1-95) and having a molecular mass of 13.4kDa. LSM2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. LSM2 is a member of the snRNP Sm proteins family. Sm-like proteins are branded in several organisms based on sequence homology with the Sm protein family. Sm-like proteins hold the Sm sequence motif that is made up of 2 regions separated by a linker of variable length which folds as a loop. The Sm-like proteins are believed to create a steady heteromer present in tri-snRNP particles, which are vital for pre-mRNA splicing. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA nad takes part in pre-mRNA splicing.
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Overview