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Overview
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LAMTOR4 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) andhaving a molecular mass of 13.1kDa. LAMTOR4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,which is a signaling complex promoting cell growth in response to growthfactors, energy levels, and amino acids. LAMTOR4 is activated by amino acids viaa mechanism which involves the lysosomal V-ATPase, the Ragulator functions as aguanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulatorand Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomeswhere it is sequentially activated.
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Overview