Recombinant Human LAMTOR4

Recombinant Human LAMTOR4

Catalog Number:
P001413313ABE
Mfr. No.:
Abe32-4092
Price:
  • Size:
    10 µg
    Quantity:
    Add to Cart:
      • Overview
        • LAMTOR4 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) andhaving a molecular mass of 13.1kDa. LAMTOR4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,which is a signaling complex promoting cell growth in response to growthfactors, energy levels, and amino acids. LAMTOR4 is activated by amino acids viaa mechanism which involves the lysosomal V-ATPase, the Ragulator functions as aguanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulatorand Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomeswhere it is sequentially activated.

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      • Properties
        • Protein Name
          Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator4, C7orf59, Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4, Chromosome7 Open Reading Frame 59, Ragulator Complex Protein LAMTOR4, UPF0539 ProteinC7orf59, LAMTOR4.
          Source
          E. coli
          Type
          Recombinant Proteins
          Purification
          Greater than 85.0% as determined by SDS-PAGE.
          Formulation
          LAMTOR4 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
          Storage
          Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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