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Overview
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MW : 27.01kD. Recombinant Human Insulin-Like Growth Factor-Binding Protein 4 is produced by our Mammalian expression system and the target gene encoding Asp22-Glu258 is expressed with a 6His tag at the C-terminus. IGFBP-4, whose full name is insulin-like growth factor-binding protein 4, is induced by forskolin and N6, O2dibutyryl sdenosine 3, or 5-cyclic monophosphate. It contains IGFBP N-terminal domain and thyroglobulin type-1 domain, and can bind IGF2. The IGF-binding proteins can prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
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Overview