Name: Recombinant Human Insulin-like Growth Factor-1 LR3 (OsrhIGF-1 LR3)
Price: Inquiry

- Overview
  - Insulin-like growth factor-1 (IGF-1) is a hormone similar in molecular structure to insulin. It primarily functions through binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R). IGF-1 is one of the most potent natural activators of the AKT signaling pathway, which stimulates cell growth and proliferation, and inhibits cell apoptosis. LR3 IGF-1 (Long Arg3 IGF-1) is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. The LR3 IGF-1 has much higher stability and biological activity.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    OryzHiExp - A Rice Endosperm Specific Expression Platform
    OryzHiExp platform uses rice endosperm cells to express various recombinant proteins and small peptides at high levels. Through this platform, innovative animal-free protein products with a wide range of applications can be produced, such as OsrHSA, OsrhTF, OsrhFN, and other recombinant growth factors.
    ADVANTAGES
    • Elimination of the potential risk of viral and other unknown contaminants
    • Avoid the quality changes from different batches, improve the repeatability of cellculture and experiment results
    • Regulatory compliant with well-defined components
    • Stable supply and manufacture capability at large scales to meet bulk processing needs
    • Simplify the downstream bio-processing or biological research
- Properties
  - Source
    
    Oryza sativa (rice)
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    More than 95% as determined by SDS-PAGE.
    
    Formulation
    
    It is lyophilized with mannitol as the stabilizer.
    
    Storage
    
    Stored at temperatures -20°C for at least 24 months. It is recommended to reconstitute LR3 IGF-1 at 100-200ug/ml in sterile water. Further dilutions can be made in other aqueous buffer. Use as soon as possible after opening. Please avoid freeze-thaw cycles.
    
    Endotoxin
    
    Less than 5 EU/mg
    
    Activity
    
    The bioactivity determined by a cell proliferation assay using Bal B/C 3T3 cell, corresponding to a specific activity of ≥ 1×10⁶ Units/mg.
    
    * For research, laboratory and manufacture use only. Not intended for direct use on humans.
- Applications
  - Application Description
    
    Mammalian cell culture; Cosmetic and beauty care; Healthcare products

The stimulating cell proliferation of rhIGF-1 measured using the Balb/c 3T3 cell line. The ED50 of OsrIGF-1 is less than 1ng/ml.

Comparison of stimulating ability of rhIGF-1 LR3 with other vendors in nine days.

Comparison of stimulating cell proliferation activity of rhIGF-1 LR3 with another vendor in four generations.

Recombinant Human Insulin-like Growth Factor-1 LR3 (OsrhIGF-1 LR3)

Recombinant Human Insulin-like Growth Factor-1 LR3 (OsrhIGF-1 LR3)

Background

The stimulating cell proliferation of rhIGF-1 measured using the Balb/c 3T3 cell line. The ED50 of OsrIGF-1 is less than 1ng/ml.

Comparison of stimulating ability of rhIGF-1 LR3 with other vendors in nine days.

Comparison of stimulating cell proliferation activity of rhIGF-1 LR3 with another vendor in four generations.

Recombinant Human Insulin-like Growth Factor-1 LR3 (OsrhIGF-1 LR3)

Recombinant Human Insulin-like Growth Factor-1 LR3 (OsrhIGF-1 LR3)

Background

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