Recombinant Human IL6R Protein with C-terminal 6×His tag

Recombinant Human IL6R Protein with C-terminal 6×His tag

Catalog Number:
P001417545ABE
Mfr. No.:
Abe32-17125
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      • Overview
        • The protein has a predicted molecular mass of 39.4 kDa after removal of the signal peptide. The apparent molecular mass of IL6R-His is approximately 55-70 kDa due to glycosylation. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

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      • Properties
        • Protein Name
          CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Purification
          The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
          Formulation
          Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
          Storage
          Store at -80°C for 12 months (Avoid repeated freezing and thawing)

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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