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Overview
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Ubiquinone Biosynthesis Protein COQ7 Homolog is a mitochondrion inner membrane and peripheral membrane protein that belongs to the COQ7 family. It is expressed primarily in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is transmitted into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. COQ7 plays a role in lifespan determination in ubiquinone-independent manner, as well as ubiquinone biosynthesis. COQ7 also acts as a potential central metabolic regulator. It has been shown that mutations in the gene are associated with increased life span. Defects of the gene slow down a variety of developmental and physiological processes, including the cell cycle, embryogenesis, post-embryonic growth, rhythmic behaviors and aging.
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