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Overview
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The protein has a predicted molecular mass of 43.2 kDa after removal of the signal peptide. The apparent molecular mass of BAFF-hFc is approximately 50-55 kDa due to glycosylation. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
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Overview