Name: Recombinant Human HER3 protein with C-terminal 6×His tag
Price: Inquiry

- Overview
  - The protein has a predicted molecular mass of 69.39 kDa after removal of the signal peptide. The apparent molecular mass of HER3-His is approximately 100-130 kDa due to glycosylation. This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
    
    Please contact us at for specific academic pricing.
- Properties
  - Protein Name
    
    HER3, ERBB3
    
    Source
    
    HEK293 cells
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
    
    Formulation
    
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    
    Storage
    
    Store at -80°C for 12 months (Avoid repeated freezing and thawing)
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Human HER3 Protein, His Tag on SDS-PAGE under reducing condition.

Recombinant Human HER3 protein with C-terminal 6×His tag

Recombinant Human HER3 protein with C-terminal 6×His tag

We Also Recommend

Recombinant human CD200 protein with C-terminal 6×His tag

Recombinant human ICOS protein with C-terminal human Fc tag

Recombinant Nucleocapsid protein with C-terminal 6×His tag