Recombinant Human Angiotensin-Converting Enzyme 2/ACE-2 (C-6His)

Recombinant Human Angiotensin-Converting Enzyme 2/ACE-2 (C-6His)

Catalog Number:
P001411851ABE
Mfr. No.:
Abe32-7375
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      • Overview
        • MW : 84.63kD. Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus. Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

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      • Properties
        • Source
          Human cells
          Type
          Recombinant Proteins
          Formulation
          Supplied as a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.
          Storage
          Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

          More Information

          UniProt
          Gene ID
          59272

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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