Rat TSH ELISA

Thyroid stimulating hormone (TSH) is a glycoprotein produced by the anterior pituitary gland. The mechanism controlling thyroid function in rats is exactly analogous to the mechanism operating in humans.Through its action on the thyroid gland, it plays a major role in maintaining normal circulating levels of the iodothyronines, T4 and T3. The production and secretion of TSH is controlled on the one side by negative feedback from circulating T4 and T3, and on the other side by the hypothalamic thyrotropinreleasing hormone (TRH).
The TSH molecule is composed of two non-identical subunits, α and β, that are bound together in a noncovalent manner. Within a species, the TSH α unit is structurally identical to the α subunits of related glycoprotein hormones (LH, FSH). The β subunits of the related hormones are structurally hormone-specific and therefore determine their unique biological activities.
Research area interests include drug toxicity, Endocrine System Disruptors (ESDs), and Thyriod function.

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