Canine TSH ELISA

Thyroid stimulating hormone (TSH, thyrotropin) in dogs is similar in function to TSH found in other mammalian species, including humans. It is a glycoprotein produced by the anterior pituitary gland. Through its action on the thyroid gland, it plays a major role in maintaining normal circulating levels of the iodothyronines, T4 and T3. The production and secretion of TSH is controlled by negative feedback from circulating T4 and T3, and by the hypothalamic hormone TRH (thyrotropin releasing hormone). The TSH molecule is composed of two nonidentical subunits, a and b, that are bound together in a noncovalent manner. Within a species, the TSH a subunit is structurally identical to the a subunits of the related glycoprotein hormones (LH, FSH and chorionic gonadotropin). The b subunit of TSH and the b subunits of the related hormones are structurally hormone-specific, and confer upon them their unique biological activities.

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