Name: Rapamycin-13C,d3 (contains d0) - Technical Grade
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- Overview
  - Binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. Induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    
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- Properties
  - Categories
    
    Enzyme Modulators
    
    CAS Number
    
    53123-88-9
    
    Molecular Weight
    
    918.18 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Kuo et al (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature, 358(6381):70-3.
    Sabers et al (1995). Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. Journal of Biological Chemistry, 270(2):815-22.
    Nazareth et al (2016). A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production. Stem Cell Reports, 6(5):679-691.