Name: Rabbit anti-Human Survivin IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (EETAKKVRRAIEQLAAMD) corresponding to amino acids 125-142 of human Survivin. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody reacts in ELISA (1: 50 dilution) and Western blot (1: 1,000) using the immunizing peptide. Survivin is a 16 kDa apoptosis inhibitor protein (IAP). It binds and inhibits the caspase-3 proteolytic activity and controls the checkpoint in the G2/M phase of the cell cycle to promote cell division by the control of microtubule stability and assembly of a normal mitotic spindle. Survivin is highly expressed during fetal development, transformed cell lines, human cancers and non-Hodgkin's lymphomas.
- Reference
  - Ambrosini, G. et al. (1997) Nat. Med. 3, 917-921.
    Li, F. et al. (1998) Nature 396, 580-584.
    Verhagen, A.M. et al. (2001) Genome Biol. 2, 3009.1-3009.10.
    Giodini, A. et al. (2002) Cancer Res. 62, 2462-2467.
    Ryan, B.M. et al. (2006) Ann. Oncol. 17, 597-604.

Rabbit anti-Human Survivin IgG fraction polyclonal antibody

Rabbit anti-Human Survivin IgG fraction polyclonal antibody

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