Name: Rabbit anti-Human SHPRH IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (DKTKKQAVGSPRKIQKETRK) corresponding to amino acids 521-540 of human SHPRH. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody reacts in ELISA and Western blot (1:500 dilution) using the immunizing peptide. SHPRH is a member of the SWI/SNF family of ATPaes/helicases, it posesses a C3HC4 RING motif characteristic of ubiquitin ligase protein and it has a fundamental role in DNA repair mechanism. Upon genotoxic stress, SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC(E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitation suppressing genomic instability. SHPRH gene is mutated in a number of cancer cell lines, including those from melanomas and ovarian cancer.
- Reference
  - Sood, R. et al. (2003) Genomics 82, 153-161.
    Unk, I. et al. (2006) Proc. Natl. Acad. Sci 103, 18107-1811.
    Motegi, A. et al. (2006) J. Cell Biol. 175, 703-708.

Rabbit anti-Human SHPRH IgG fraction polyclonal antibody

Rabbit anti-Human SHPRH IgG fraction polyclonal antibody

We Also Recommend

anti-AAV VP1 mouse monoclonal, A1, lyophilized, purified

anti-AAV VP1/VP2 mouse monoclonal, A69, lyophilized, purified

Anti-AAV VP1/VP2/VP3 mouse monoclonal, B1, AFDyeTM 488 Conjugate