Rabbit anti-Human S-phase Kinase-associated protein 1A (Skp1) IgG fraction polyclonal antibody

Rabbit anti-Human S-phase Kinase-associated protein 1A (Skp1) IgG fraction polyclonal antibody

Catalog Number:
A001277517AUS
Mfr. No.:
AUST_PCA-3040a-9
Price:
$760
  • Size:
    1mg
    Quantity:
    Add to Cart:
      • Overview
        • IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (AQVRKENQWCEEK) corresponding to amino acids 151-163 of human Skp1 . The IgG fraction was purified using Protein G-Sepharose.

          Please contact us at for specific academic pricing.

      • Properties
        • Antibody Type
          polyclonal
          Formulation
          Solution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
          Storage
          Store at -20°C.

          * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

      • Applications
        • Application Description
          This polyclonal antibody reacts in ELISA (1: 250 dilution) and Western blot (1:1,000 dilution) using the immunizing peptide. S-phase kinase-associated protein 1A (Skp1) is a component of the SCF ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. Skp1 interacts directly with cullin 1 and F-box proteins in the SCF complex. It is also involved in the control of beta-catenin levels and the activity of beta-catenin dependent TCF transcription factors.
      • Reference
        • Schulman, B.A. et al. (2000) Nature 408, 381-386.
          Zheng, N. et al. (2002) Nature 416, 703-709.
          Cardoso, T. & Pagano, M. (2006) Nat. Rev. Mol. Cell Biol. 5, 739-751.

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