Name: Rabbit anti-Human PUMA alpha (epitope a) IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (ARARQEGSSPEPVEG) corresponding to amino acids 2 - 16 of human PUMA isoform alpha. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody reacts in ELISA using the immunizing peptide and it recognizes PUMA alpha (23 kDa) and additional protein band of 60 kDa in Western Blot of HeLa cell lysate (1: 1,000 dilution). PUMA (p53 up-regulated modulator of apoptosis) belongs to the Bcl-2 family and may be a direct mediator of p53-induced apoptosis. PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta, both bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53.
- Reference
  - Yu, J. et al. (2001) Mol. Cell 7, 763-68
    Nakano, K. & Vousden, K.H. (2001) Mol. Cell 7, 683-694.
    Schuler, M. & Green, D.R. (2001) Bioch. Soc. Trans. 29, 684-688.
    Chipuk, J.E. & Green, D.R. (2006) 13, 994-100

Rabbit anti-Human PUMA alpha (epitope a) IgG fraction polyclonal antibody

Rabbit anti-Human PUMA alpha (epitope a) IgG fraction polyclonal antibody

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