Name: Rabbit anti-Human N-Myc IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (SPYVESEDAPPQKK) corresponding to amino acids 337-349 of human N-Myc. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody reacts in ELISA and Western blot assays (1: 500 dilution) using the immunizing peptide. N-Myc is a 49.5 kDa nuclear phosphoprotein that contains a basic helix-loop-helix leucine zipper domain involved in DNA binding and protein dimerization. It regulates gene expression by dimerizing with itself or other helix-loop-helix proteins and this complex binds to DNA E-box sequences of regulated genes. N-Myc is expressed in high levels during embryonic development and in the adult during B-cell differentiation. It is overexpressed in a variety of tumors, aminly neuroblastomas and is associated with rapid progression and poor prognosis.
- Reference
  - Slamon, D.J. et al. (1986) Science 232, 768-77.
    Eisenman, R.N. (2001) Genes & Dev. 15, 2023-2030.
    Knoepfler, P.S. et al. (2006) EMBO J. 25, 2723-2734.

Rabbit anti-Human N-Myc IgG fraction polyclonal antibody

Rabbit anti-Human N-Myc IgG fraction polyclonal antibody

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