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Rabbit anti-Human Cyclin-dependent Kinase 4 (Cdk4) IgG fraction polyclonal antibody

Rabbit anti-Human Cyclin-dependent Kinase 4 (Cdk4) IgG fraction polyclonal antibody

Catalog Number:
A001277513AUS
Mfr. No.:
AUST_PCA-3010a-9
Price:
$760
  • Size:
    1mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (QHSYLHKDEGNPE) corresponding to amino acids 291-303 of human Cdk4. The IgG fraction was purified using Protein G-Sepharose.

          Please contact us at for specific academic pricing.

      • Properties
        • Antibody Type
          polyclonal
          Formulation
          Solution at 1.0 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
          Storage
          Store at -20°C.

          * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

      • Applications
        • Application Description
          This polyclonal antibody reacts in ELISA (1: 250 dilution) and Western blot (1: 1,000 dilution) using the immunizing peptide. Cyclin-dependent kinase 4 (Cdk4) is a 34 kDa catalytic subunit of the protein kinase complex and belongs to the Ser/Thr protein kinase family. Cdk4 forms a complex with D-type cyclins and may regulate cell growth during G1 phase of the cell cycle. Cdk4 also associates with Cdk inhibitor p16 that down-regulates Cdk4 activity. Mutations in Cdk4 are associated with tumorigenesis of a variety of cancers.
      • Reference

        • Khatib, Z.A. et al. (1993) Cancer Res. 53, 5535-5541.
          Pines, J. (1995) Biochem. J. 308, 697-711.
          Bockstaele, L. et al. (2006) Cell Div. 1: 25.

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