Name: Rabbit anti-Human Cullin4a (CUL 4a) IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (MADEAPRKGSFSALVGRTNG) corresponding to amino acids 1-20 of human Cullin 4a. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody can be used in ELISA (1: 500 dilution), immunocitochemistry (1:100 dilution) and it recognizes Cullin 4A (75 kDa) in Western blot of HeLa lysate (1: 1,000 dilution). Cullins (1, 2, 3, 4a, 5 and 7) are a family of proteins that assemble a large number of ubiquitin ligases to catalyse polyubiquitiation, as well as binding to various specific factors to recruit substrates. Cullin 4 (CUL 4) serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits of SCF. It plays a role in the polyubiquitination of CDT1 in response to radiation-induced DNA damage and may be important for subsequent DNA repair.
- Reference
  - Chen, L-C. et al. (1998) Cancer Res. 58, 3677-368
    Dai, Q. & Wang, H. (2006) Cell Div. 1, 14.
    Higa, L.A et al. (2006) Cell Cycle 5, 1675-1680.
    Angers, S. et al. (2006) Nature 443, 590-59

Rabbit anti-Human Cullin4a (CUL 4a) IgG fraction polyclonal antibody

Rabbit anti-Human Cullin4a (CUL 4a) IgG fraction polyclonal antibody

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