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Rabbit anti-Human Bax IgG fraction polyclonal antibody

Rabbit anti-Human Bax IgG fraction polyclonal antibody

Catalog Number:
A001277500AUS
Mfr. No.:
AUST_PCA-2075a-9
Price:
$760
  • Size:
    1mg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (MDGSGEQPRGGGPTSSEQIMK) corresponding to amino acids 1 - 21 of human Bax. The IgG fraction was purified using Protein G-Sepharose.

          Please contact us at for specific academic pricing.

      • Properties
        • Antibody Type
          polyclonal
          Formulation
          Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
          Storage
          Store at -20°C.

          * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.

      • Applications
        • Application Description
          This polyclonal antibody reacts in ELISA using the immunizing peptide and it recognizes two protein bands corresponding to 20 (monomer) and 40 kDa (dimer) of Bcl-2 in Western Blot of HL-60 cell lysate. Bax belongs to Bcl-2 protein family and accelerates the apoptosis by binding to the repressor Bcl-2. It can form oligomers and targets mitochondrial membrane inducing an increase in the membrane permeability which leads to the release of cytochrome c from mitochondria and the activation of the caspase pathway. Bax is considered a tumor suppressor.
      • Reference

        • Oltvai, Z.N. et al. (1993) Cell 74, 609-619.
          Reed, J.C. (1994) J. Cell Biol. 124, 1-6. Wei, M.C. (2001) Science 292, 727-720.

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