Name: Rabbit anti-Human B-cell Leukaemia/lymphoma 2 (Bcl-2) IgG fraction polyclonal antibody
Price: 760.00 USD

- Overview
  - IgG fraction from rabbit polyclonal antibody obtained by immunizing rabbits with a synthetic peptide (GAAPAPGIFSSQPG) corresponding to amino acids 41 - 54 of human Bcl-2. The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    polyclonal
    
    Formulation
    
    Solution at 1 mg/mL in PBS. Some of the liquid in the vial could have evaporated with changes in the final volume. However, the mass of the protein is still inside the vial.
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This polyclonal antibody reacts in ELISA using the immunizing peptide and it recognizes a 25 kDa protein in Western Blot of extract from Jurkat cells. Bcl-2 is a protein localized on the mitochondrial outer membrane, endoplasmic reticulum, and nuclear envelope. It supresses apoptosis modulated by homodimerization or association with Bax and Bad, two cell death promoters. It may contribute to tumorigenesis by prolonging cell survival and by mutations in the Bcl-2 gene.
- Reference
  - 1. Reed, J.C. (1997) Nature 387, 773 - 776. Chan, S.L. & Yu, V.C. (2004) Clin. Exp. Pharmacol. Physiol. 31, 119 - 128.
    2. Sorenson, C.M. (2004) Biochim. Biophys. Acta 1644, 169-177.
    3. Kirkin, V. et al. (2004) Biochim. Biophys. Acta 1644, 229 - 249.

Rabbit anti-Human B-cell Leukaemia/lymphoma 2 (Bcl-2) IgG fraction polyclonal antibody

Rabbit anti-Human B-cell Leukaemia/lymphoma 2 (Bcl-2) IgG fraction polyclonal antibody

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