Name: (R)-(+)-Atenolol
Price: 329.00 USD

- Overview
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    Background
    
    (R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol [1]. Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. Atenolol is used for a number of conditions including hypertension, angina, long QT syndrome, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, and the symptoms of alcohol withdrawal. β1-adrenergic receptor is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue. Pharmacokinetic data of the time course of plasma concentrations over 24 h following oral administration of 50 mg (R)-(+)-Atenolol revealed that the Cmax, AUC, and t1/2 values were 326±87 ng/ml, 2599±639 ng×h/ml, and 8.9±2.9 h, respectively [1].
- Properties
  - Categories
    
    less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol.
    
    Alternative Name
    
    4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
    
    CAS Number
    
    56715-13-0
    
    Molecular Formula
    
    C14H22N2O3
    
    Molecular Weight
    
    266.3
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤5mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    NC(CC1=CC=C(OC[[email protected]](O)CNC(C)C)C=C1)=O
    
    * For Research Use Only