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Overview
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Pyrazinamide is a sparingly soluble bactericidal antitubercular drug.
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Background
The mechanism of pyrazinamide is not entirely understood. It is speculated that pyrazinamide enters a target cell and is converted into pyrazinoic acid (POA) which disrupts normal membrane permeability functions. Internal pH of the cell begins to decrease as POA accumulates in the cell’s cytoplasm which is thought to inhibit fatty acid synthase activity.
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