Name: PSI-6206
Price: 206.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    PSI-6206 (as known as RO-2433 or GS-331007), β-D-2’-deoxy-2’-fluoro-2’-C-methyluridine, is the deaminated derivative of PSI-6130, β-D-2’-deoxy-2’-fluoro-2’-C-methylcytidine, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system. PSI-6206, itself, does not shown any inhibitory activity towards HCV replication in the HCV subgenomic replicon system. However, the its triphosphate form, RO2433-TP, is a potent inhibitor of RNA synthesis by HCV polymerase, which inhibits both the RNA sysnthesis activity of HCV replicase (IC50 = 1.19 uM) and the RNA synthesis activity of the recombinant HCV Con1 NS58 on a heteropolymeric RNA template derived from the 3’-end of the negative strand of the HCV genome (IC50 = 0.52 uM and Ki = 0.141 uM).
- Properties
  - Alternative Name
    
    1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione
    
    CAS Number
    
    863329-66-2
    
    Molecular Formula
    
    C10H13FN2O5
    
    Molecular Weight
    
    260.22
    
    Appearance
    
    A solid
    
    Purity
    
    99.97%
    
    Solubility
    
    ≥13.1 mg/mL in DMSO; ≥24.15 mg/mL in EtOH with ultrasonic; ≥48.7 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Eyer L, Šmídková M, et al. "Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus. Antiviral Res." 2016 Jul 28;133:119-129. PMID:27476046
    2. Eyer L, Nencka R, et al. "Nucleoside inhibitors of Zika virus." J Infect Dis. 2016 May 27. pii:jiw226. PMID:27234417
    3. Rower, Joseph E, et al. "Validation and application of an LC-MS/MS method to determine the concentrations of sofosbuvir anabolites in cells." Antimicrobial agents and chemotherapy (2015): AAC-01693. PMID:26416874

PSI-6206

PSI-6206

Background

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