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Semagacestat (LY450139)

Semagacestat (LY450139)

Catalog Number:
L002369393APE
Mfr. No.:
APE-A8190
Price:
$298
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      • Overview

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          Background

          Semagacestat (also known as LY450139), [(2S)-2-hydroxy-N-((2S)-1-((1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of Alzheimer’s disease (AD). It reduces the rate of formation of amyloid-β (Aβ), a major component of the neuritic plaque in the brains of AD patients, in human subjects and animal models including mice, beagle dogs and guinea pigs. According to previous studies, semagacestat slows the accumulation of Aβ in the brains of transgenic mice overexpressing mutant human amyloid precursor protein V717F (PDAPP mice) and exhibits a dose-dependent decrease of plasma in AD patients.

      • Properties
        • Alternative Name
          LY-450139, LY 450139,Semagacestat; (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide
          CAS Number
          425386-60-3
          Molecular Formula
          C19H27N3O4
          Molecular Weight
          361.44
          Appearance
          A solid
          Purity
          98.68%
          Solubility
          insoluble in H2O; ≥18.05 mg/mL in DMSO; ≥40.3 mg/mL in EtOH with ultrasonic
          Storage
          Store at -20°C

          * For Research Use Only

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