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PMS2 Rabbit mAb

PMS2 Rabbit mAb

Catalog Number:

A001549922RED

Mfr. No.:

RDSA66520

Price:

$470

Size:

100μL

Quantity:

Add to Cart:

Overview
- Please contact us at for specific academic pricing.
  
  Background
  
  Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  A synthesized peptide derived from human PMS2
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  
  Storage
  
  Store at -20°C. Avoid freeze / thaw cycles.
  
  Antigen
  
  DNA mismatch repair gene;DNA mismatch repair protein PMS2;HNPCC4;PMS1 protein homolog 2 (UniProt:P54278)
  
  * This product is for Research Use Only.

Applications

Application

WB; IHC; ICC/IF; IP; FC

Application	Dilutions
WB	1:500-1:2000
IHC	1:50-1:200
ICC/IF	1:50-1:200
IP	1:50
FC	1:50

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