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Platelet Membrane Glycoprotein IIB Peptide (296-306)

Platelet Membrane Glycoprotein IIB Peptide (296-306)

Catalog Number:
L002368273APE
Mfr. No.:
APE-A1018
Price:
$153
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      • Overview

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          Background

          Human alloantisera specific for either the Bak' or Bakb allele have been shown to react exclusively with the heavy chain of membrane glycoprotein (GP) Ilb.
          GPllb is composed of a 125 Kd heavy chain that is disulfide-linked to a 23 Kd light chain. Hydropathicity analysis of the cDNA sequence indicates that GPllb is anchored to the platelet through a single transmembrane domain located within 20 amino acids of the C-terminus of the light chain.
          The GPllb-IIa complex is a Ca2+-dependent heterodimer that, on activated platelets, can bind one of the four different adhesive proteins. (i.e. fibrinogen, fibronectin, von Willebrand factor, or vitronectin ).

          1. Bray PF, Rosa J-P, Lingappa VR, Kan YW, McEver RP, Shuman MA: Biogenesis of the platelet receptor for fibrinogen: Evidence for separate precursors for glycoproteins Ilb and IIIa. Proc Natl Acad Sci USA 83:1480,1986
          2. Silver SM, McDonough MM, Vilaire G, Bennett JS: The in vitro synthesis of polypeptides for the platelet membrane glycoproteins IIb and IIIa. Blood 69:1031, 1987.
          3. Phillips DR, Charo IF, Parise LV, Fitzgerald LA : The platelet membrane glycoproteins IIb-IIIa co,plex. Blood 71:831-843, 1988

      • Properties
        • Alternative Name
          H2N-Thr-Asp-Val-Asn-Gly-Asp-Gly-Arg-His-Asp-Leu-OH
          Molecular Formula
          C47H75N17O20
          Molecular Weight
          1198.2
          Appearance
          A solid
          Purity
          98.92%
          Solubility
          ≥119.8 mg/mL in DMSO; ≥5 mg/mL in EtOH with ultrasonic; ≥50 mg/mL in H2O
          Storage
          Store at -20°C

          * For Research Use Only

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