Name: Piperacillin
Price: 210.00 USD

- Overview
  - Piperacillin is a semi-synthetic, extended spectrum fungistatic β-lactam fourth-generation ureidopenicillin. It was developed by Toyama Chemical Co, Tokyo, Japan and is derived from Ampicillin. Piperacillin is commonly used in combination with the β -lactamase inhibitor Tazobactam. It can be used to study multidrug resistance.
    Piperacillin is sparingly soluble in aqueous solution.
    
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    Background
    
    β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    61477-96-1
    
    Molecular Formula
    
    C23H27N5O7S
    
    Molecular Weight
    
    517.55
    
    Appearance
    
    White crystalline powder
    
    Solubility
    
    Sparingly soluble in aqueous solution
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): 2.0-4.0%
    PH: 2.0-4.5
    Assay: (on dried basis): 96.0-103.0%
    Heavy Metals: ≤ 0.002%
    Optical Rotation: +155° to +175°
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Piperacillin is broad-spectrum, targeting a wide range of susceptible Gram-positive and Gram-negative bacteria. It targets both aerobic and anaerobic bacteria. It can be used against Enterococcus species, Pseudomonas aeruginosa, and E. coli.
    
    Microbiology Applications: Piperacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram- positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. It is commonly used in a mixture with the β-lactamase inhibitor Tazobactam which enhances is effectiveness. Representative MIC values include:
    Neisseria spp. 0.015 µg/mL – 32 µg/mL
    Bacteroides fragilis 0.25 µg/mL - 32 µg/mL
    
    Plant Biology Applications: In vitro activity of Piperacillin against Agrobacterium tumefaciens strains LBA4404 and EHA101 was examined and found to be effective in eliminating the bacteria involved in Agrobacterium-mediated plant genetic transformation (Ogawa and Mii, 2004).

Datasheet

MSDS

Documents

Susceptibility and Resistance Data

Piperacillin

Piperacillin

Background

Documents

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