Phospho-GR (Ser211) Rabbit Polyclonal Antibody

Phospho-GR (Ser211) Rabbit Polyclonal Antibody

Catalog Number:
A001450543ZEN
Mfr. No.:
Zen-370340
Price:
  • Size:
    100μl
    Quantity:
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

      • Properties
        • Host
          rabbit
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Synthetic phosphopeptide derived from human GR around the phosphorylation site of Serine 211.
          Purification
          Affinity Purified
          Conjugate
          Unconjugated
          Formulation
          1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
          Antigen
          (Gene ID:2908; UniProt:P04150)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          WB; IHC-P
        • Application Dilutions
          WB 1/500-1/1000
          IHC 1/50-1/200

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