Phospho-Glycogen synthase 1(Ser645) Rabbit Polyclonal Antibody

Phospho-Glycogen synthase 1(Ser645) Rabbit Polyclonal Antibody

Catalog Number:
A001450544ZEN
Mfr. No.:
Zen-370339
Price:
  • Size:
    100μl
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Glycogen is a polysaccharide of glucose and serves as an energy storage in mammalian muscle and liver. Glycogen synthase catalyzes the rate-limiting step of glycogen biosynthesis and has two major isoforms in mammals -- muscle isoform (GYS1) and liver isoform (GYS2) respectively. Glycogen synthase kinase-3α (GSK-3α) and glycogen synthase kinase-3β (GSK-3β) phosphorylate glycogen synthase at multiple sites in its C-terminus (Ser641, Ser645, Ser649 and Ser653) inhibiting its activity. Hypoxia alters glycogen metabolism including temporal changes of GYS1 expression and phosphorylation in cancer cells, suggesting the role of metabolic reprogramming of glycogen metabolism in cancer growth.

      • Properties
        • Host
          rabbit
          Isotype
          IgG
          Reactivity
          human; rat
          Immunogen
          Synthetic phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Serine 645.
          Purification
          Affinity Purified
          Conjugate
          Unconjugated
          Formulation
          1 mg/ml in PBS with 0.05% sodium azide,pH 7.3.
          Storage
          Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
          Antigen
          (Gene ID:2997; UniProt:P13807)

          * Research Use Only Product (RUO). Not for Diagnosis or Therapeutic Use.

      • Applications
        • Application
          WB
        • Application Dilutions
          WB 1/500-1/1000

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