Name: Phorbol 12,13-dibutyrate
Price: 281.00 USD

- Overview
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    Background
    
    Phorbol 12,13-dibutyrate, a phorbol ester, is an activator of PKC, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and DAG or phorbol ester-unresponsive subtype (ζ). PKC plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. Phorbol esters are able to replace the endogenous activator DAG in the stimulation of PKC, and participate in the multistage process of tumor formation and progression.
    
    1. Geiges D, Meyer T, Marte B, et al. Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochemical Pharmacology, 1997, 53(6): 865-875.
    2. Middleton JP, Khan WA, Collinsworth G, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. Journal of Biological Chemistry, 1993, 268(21): 15958-15964.
    3. Scribner JD, Boutwell RK. Inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. European Journal of Cancer, 1972, 8(6): 617-621.
- Properties
  - Categories
    
    A protein kinase C (PKC) activator
    
    Alternative Name
    
    (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulene-9,9a-diyl dibutyrate
    
    CAS Number
    
    37558-16-0
    
    Molecular Formula
    
    C28H40O8
    
    Molecular Weight
    
    504.61
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <25.23mg/ml in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]@]1([[email protected]](C=C(C)C2=O)[[email protected]]32O)[[email protected]@H](C=C(CO)C3)[[email protected]](C4(C)C)[[email protected]]4([[email protected]@H]([[email protected]]1C)OC(CCC)=O)OC(CCC)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate

Background

Documents

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