PF-622

- Overview
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    Background
    
    PF-622 is a potent, time-dependent, irreversible FAAH inhibitor [1].Fatty acid amide hydrolase (FAAH), belongs to a member of an unusual class of serine hydrolases, is an integral membrane enzyme involved in regulating the fatty acid amide family of lipid transmitters. Genetic or pharmacological inactivation of FAAH leads to elevated endogenous levels of fatty acid amides with analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes. The FAAH is an attractive drug target for the treatment of pain [1].In vitro: PF-622 inhibited the activity of FAAH in a time-dependent manner with the IC50 values of 0.99 and 0.033 μM in human recombinant FAAH for 5 and 60 minutes, respectively [1]. In various human and murine tissue proteome samples, PF-622 showed highly selectivity for FAAH in relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM [1]. PF-622 at 1 μM decreased IL-2 production in both healthy subjects and in HCV patients [2].
    
    [1] Ahn K, Johnson D S, Fitzgerald L R, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity[J]. Biochemistry, 2007, 46(45): 13019-13030.
    [2] Patsenker E, Sachse P, Chicca A, et al. Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation[J]. International journal of molecular sciences, 2015, 16(4): 7057-7076.
- Properties
  - Alternative Name
    
    N-phenyl-4-(2-quinolinylmethyl)-1-piperazinecarboxamide
    
    CAS Number
    
    898235-65-9
    
    Molecular Formula
    
    C21H22N4O
    
    Molecular Weight
    
    346.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤0.3mg/ml in ethanol;2mg/ml in DMSO;3mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

PF-622

Background

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