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PF-431396

PF-431396

Catalog Number:
L002369694APE
Mfr. No.:
APE-A8692
Price:
$196
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells.

      • Properties
        • Alternative Name
          N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
          CAS Number
          717906-29-1
          Molecular Formula
          C22H21F3N6O3S
          Molecular Weight
          506.5
          Appearance
          A solid
          Purity
          98.00%
          Solubility
          insoluble in H2O; insoluble in EtOH; ≥18.1 mg/mL in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference

        • 1. Panagi I, Jennings E, et al. "Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization." Cell Host Microbe. 2020;27(1):41–53.e6. PMID:31862381

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