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PF-431396

PF-431396

Catalog Number:

L002369694APE

Mfr. No.:

APE-A8692

Price:

$196

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells.
- Properties
  - Alternative Name
    
    N-methyl-N-[2-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide
    
    CAS Number
    
    717906-29-1
    
    Molecular Formula
    
    C22H21F3N6O3S
    
    Molecular Weight
    
    506.5
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥18.1 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
    
    * For Research Use Only
- Reference
  - 1. Panagi I, Jennings E, et al. "Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization." Cell Host Microbe. 2020;27(1):41–53.e6. PMID:31862381

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