Pepstatin A - Amerigo Scientific

- Overview
  - Pepstatin A, a pentapeptide isolated from Streptomyces sp. is a strong inhibitor of aspartyl proteases such as pepsin, cathepsin D, and renin. Pepstatin is active against HIV-1 and Plasmodium falciparum. HIV-infected H9 cells incubated with pepstatin A at 10-4M for 2, 4 or 10 days had significantly reduced HIV core antigen (p24) and no infectious HIV. Pepstatin A exerts its antimalarial activity via P. falciparum plasmepsin II binding sites. Pepstatin A suppresses NF-κB ligand (RANKL)-induced osteoclast differentiation and decreases the expression of nuclear factor of activated T cells c1 (NFATc1), suggesting that suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression.
    
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- Properties
  - CAS Number
    
    102-07-8
    
    Molecular Formula
    
    C34H63N5O9
    
    Molecular Weight
    
    685.9
    
    Appearance
    
    White solid
    
    Solubility
    
    Soluble in methanol or DMSO
    
    Other Properties
    
    Source: Actinomyces sp
    
    * For research use only