Penicillin G, EvoPure®

- Overview
  - Penicillin is a member of the Î²-lactam antibiotics and was one of the first discovered antibiotics.
    Penicillin G, EvoPure is sparingly soluble in aqueous solution (0.210 mg/mL).
    
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    Background
    
    Î²-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBPâs are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to Î²-lactams is commonly due to cells containing plasmid encoded Î²-lactamases.
- Properties
  - CAS Number
    
    61-33-6
    
    Molecular Formula
    
    C16H18N2O4S
    
    Molecular Weight
    
    334.39
    
    Appearance
    
    White or almost white crystalline powder
    
    Solubility
    
    Water: Freely soluble
    
    Other Properties
    
    Source: Penicillium spp.
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Penicillin is targets primarily gram positive bacteria including Staphylococcus and Streptococcus species
    
    Microbiology Applications: Penicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Streptococcus pneumoniae 0.004 Âµg/mL â 0.5 Âµg/mLStreptococcus agalactiae 0.03 Âµg/mL â 0.06 Âµg/mL Mycoplasma Media Supplements Penicillin can be used as a selective agent in several types of isolation media: Mycoplasma Agar - Mycoplasma Supplement G Mycoplasma Agar - Mycoplasma Supplement P