Name: PAX6 Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: PAX6
  Area: Neuroscience / Stem Cell
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019]
Properties
- Host
  
  Rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  Human, Mouse, Rat
  
  Clone
  
  pAb
  
  Immunogen
  
  Synthetic peptide / encompassing a sequence within the center region.
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  100mM Tris Glycine, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  
  Molecular Weight
  
  54, 34
  
  * For research use only.