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Overview
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Background
Parkin is a zinc-finger protein that is related to ubiquitin at the amino terminus. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin-E during neuronal apoptosis.
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- Properties
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Overview