Name: PAC-1
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    First procaspase-activating compound (PAC-1) is a small-molecule activator of procaspase-3 that directly catalyzes the maturation of procaspase-3 to the active caspase-3 by inducing the cleavage of procaspase-3 in a time-dependent manner. As a result of the direct and immediate activation of procaspase-3, PAC-1 potently induces apoptosis in cancer cell lines. The PAC-1 induced apoptosis has been observed to be proportional to the concentrations of procaspase-3 inside the cells of primary colon cancer isolates. Study results have demonstrated that PAC-1 is able to induce cell death in both primary cancerous cells and adjacent normal tissues with 50% inhibition concentration IC50 values ranging from 0.003 to 1.41 μM and 5.02 to 9.98 μM respectively.
    
    Reference:
    Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho MH, Doerge DR, Helferich WG, Hergenrother PJ. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50. Epub 2006 Aug 27.
- Properties
  - Categories
    
    Procaspase-3 activator
    
    Alternative Name
    
    2-(4-benzylpiperazin-1-yl)-N'-[(Z)-(6-oxo-5-prop-2-enylcyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide
    
    CAS Number
    
    315183-21-2
    
    Molecular Formula
    
    C23H28N4O2
    
    Molecular Weight
    
    392.49
    
    Appearance
    
    A solid
    
    Purity
    
    98.35%
    
    Solubility
    
    insoluble in H2O; ≥13.4 mg/mL in DMSO; ≥6.87 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O
    
    * For Research Use Only
- Reference
  - 1. Wenbo Huo, Jinghua Yu, et al. "Caspase-3 inhibitor inhibits enterovirus D68 production." J Microbiol 2020 Sep;58(9):812-820. PMID:32870487
    2. Liu H, Kai L, et al. "LPS Inhibits Fatty Acid Absorption in Enterocytes through TNF-α Secreted by Macrophages." Cells. 2019 Dec 12;8(12). pii: E1626. PMID:31842409
    3. Martin PK, Marchiando A, et al. "Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota." Nat Microbiol. 2018 Oct;3(10):1131-1141. PMID:30202015

Documents

COA (Certificate Of Analysis)

HPLC

NMR (Nuclear Magnetic Resonance)

MSDS (Material Safety Data Sheet)

Datasheet

PAC-1

PAC-1

Background

Documents

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