Name: MG-262
Price: 378.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    MG-262 (also known as Z-Leu-Leu-Leu-B(OH)2), a boronic peptide acid, is a potent proteasome inhibitor that selectively and reversibly inhibits the chymotryptic activity of the proteasome. It consists of a peptide and boronic acid moiety which are functional to proteasome inhibition. According to previous studies, MG-262 is capable of reducing the viability of nasal mucosa and polyp fibroblasts, provoking cell growth arrest, inhibiting DNA replication and retinoblastoma phosphorylation, increasing expression of the cell cycle inhibitor p21 and p27, and inducing cell death via loss of mitochondrial membrane potential, caspase-3 and poly(ADP-ribose) polymerase activation, induction of c-Jun phosphorylation and mitogen-activated protein kinase phosphatase-1 expression.
- Properties
  - Alternative Name
    
    PS-III,MG262,MG 262; [(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid
    
    CAS Number
    
    179324-22-2
    
    Molecular Formula
    
    C25H42BN3O6
    
    Molecular Weight
    
    491.44
    
    Appearance
    
    A solid
    
    Purity
    
    99.82%
    
    Solubility
    
    ≥24.57 mg/mL in DMSO; insoluble in H2O; ≥96.4 mg/mL in EtOH
    
    Storage
    
    Store at -20°C. The product is not stable in solution, please dissolve it immediately before use.
    
    * For Research Use Only
- Reference
  - 1. Fullbright G, Rycenga HB, et al. "p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair." Mol Cell Biol. 2016 Nov 14;36(23):2983-2994. PMID:27644328

MG-262

MG-262

Background

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