Name: KN-62
Price: 300.00 USD

- Overview
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    Background
    
    KN-62, 1-[N,O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosy]-4-phenylpiperazine is a highly selective inhibitor of the calcium dependent calmodulin protein kinase II (CAMKII), which binds to the calmodulin binding site of CAMKII and consequently does not inhibit other classes of calmodulin-sensitive kinases. In previous studies, KN-62 exhibits inhibitory effects on the regulated secretion of insulin by hetero-junction with intrinsic thin-layer (HIT) cells and the cholecystokinin secretion from stanniocalcin-1 (STC-1) enteroendocrine cells due to a block of Ca2+ influx through L-type Ca2+ channels in the olasma membrane. It also inhibits both insulin- and hypoxia-stimulated glucose transport activity by 46% and 40% respectively in skeletal muscle.
- Properties
  - Alternative Name
    
    [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate
    
    CAS Number
    
    127191-97-3
    
    Molecular Formula
    
    C38H35N5O6S2
    
    Molecular Weight
    
    721.9
    
    Appearance
    
    A solid
    
    Purity
    
    99.32%
    
    Solubility
    
    ≥36.1 mg/mL in DMSO; insoluble in H2O; ≥15.88 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only
- Reference
  - 1. Anna Visa, Lía Alza, et al. "Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling." Biomed Pharmacother. 2022 May;149:112881. PMID: 35367758

KN-62

KN-62

Background

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