pAAVdual-GfaABC1D-EGFP

pAAVdual-GfaABC1D-EGFP is used to produce AAV-GfaABC1D-EGFP virus using novel AAVdual production system. In this plasmid, the regular single strand AAV genome with a GfaABC1D promoter and an EGFP reporter is cloned into our novel Ad helper plasmid, mini-pHelper. AAV-GfaABC1D-EGFP viruses can be generated by co-transfection of this plasmid with regular AAV helper (pRCap) plasmids, carrying AAV2 rep gene and different cap genes, without adding additional Ad helper plasmid to supply E2A, E4orf6 and VA RNA functions.
The GfaABC1D promoter is a specific regulatory DNA sequence that controls the expression of the GfaABC1D gene. This promoter is typically associated with driving gene expression in glial fibrillary acidic protein (GFAP)-expressing cells, particularly astrocytes in the central nervous system. The GfaABC1D promoter is a shortened version of the longer GFAP promoter, optimized for more specific or efficient expression in certain experimental contexts. This promoter is widely used in gene therapy, neuroscience, and molecular biology to target gene expression specifically to astrocytes. Researchers often use it in experiments where controlling gene expression in these glial cells is crucial, such as in studies of neurodegenerative diseases, brain injury, or astrocyte function.

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