Orexin A (human, rat, mouse) , >95% by HPLC

Orexin A (human, rat, mouse) , >95% by HPLC

Catalog Number:
P004516876LIF
Mfr. No.:
PEPTIDE-OX-050
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  • Size:
    0.5mg
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      • Overview

        • Endogenous OX1 and OX2 orexin receptor agonist.
          Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.

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      • Properties
        • Categories
          Peptides
          Alternative Name
          Hypocretin 1
          Molecular Formula
          C152H243N47O44S4
          Molecular Weight
          3561.12
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble to 1 mg/ml in water
          Other Properties
          Sequence: Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14),XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2
          Modification: X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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