Name: Oleyloxyethyl Phosphorylcholine
Price: 242.00 USD

- Overview
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    Background
    
    IC50: 6.2 μM for porcine pancreatic PLA2Oleyloxyethyl phosphorylcholine is a PLA2 inhibitor. Phospholipases A2 (PLA2s) are enzymes releasing fatty acids from glycerol. This particular phospholipase can specifically recognize the sn-2 acyl bond of phospholipids and catalytically hydrolyze the bond releasing arachidonic acid and lysophosphatidic acid. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active eicosanoids, which are categorized as anti-inflammatory and inflammatory mediators.In vitro: To examine the phospholipids including oleyloxyethyl phosphorylcholine as PLA2 inhibitors, the enzyme assay was employed. Determinations were performed below critical micelle concentration. Porcine pancreatic PLA2 and phospholipid inhibitor were preincubated for 2 min at 37°C in buffer at pH 8.5. Introduction of [l4C]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°C. In this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of PLA2 with an IC50 of 6.2 μM for porcine pancreatic PLA2 [1].In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    1-O-9Z-octadecenylethyleneglycol-2-O-phosphorylcholine
    
    CAS Number
    
    84601-19-4
    
    Molecular Formula
    
    C25H52NO5P
    
    Molecular Weight
    
    477.7
    
    Appearance
    
    A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤16mg/ml in DMSO;16mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Oleyloxyethyl Phosphorylcholine

Oleyloxyethyl Phosphorylcholine

Background

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