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OF-1

OF-1

Catalog Number:
L002370702APE
Mfr. No.:
APE-B4895
Price:
$260
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      • Overview

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          Background

          OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd value = 100nM and 500 nM, respectively; >100-fold selectivity over majority of other bromodomains).BRPF (BRomodomain and PHD Finger containing) protein family are scaffolding proteins that assembles MYST histone acetyltransferase complexes. MYST complexes play important role in DNA repair, recombination, replication and transcription activation.In cellular thermal shift assay (CETSA) of full length BRPF1B, OF-1 enhanced thermal stability at 1 µM. In BRPF2 FRAP assay, OF-1 showed accelerated FRAP recovery at 5µM. OF-1 exhibited modest general cytotoxicity.

          [1]. OF-1 - A chemical probe for BRPF bromodomains. (2010, October 13). SGC. Retrieved from http://www.thesgc.org/chemical-probes/OF-1

      • Properties
        • Alternative Name
          4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
          CAS Number
          919973-83-4
          Molecular Formula
          C17H18BrN3O4S
          Molecular Weight
          440.31
          Purity
          98.00%
          Solubility
          insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

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